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Engineering of Komagataella phaffii for efficient secretory expression of highly hydrophilic recombinant type III human-like collagen

2026-01-22

Abstract excerpt

<title>Abstract</title> <p> Collagen, a key extracellular matrix protein, regulates cell adhesion, proliferation, and tissue integrity for skin health. In this study, a novel human-like type III collagen was engineered by substituting hydrophobic GXY triplets in the core fragment (Gly201-Asn498) of the human α1(III)type chain with hydrophilic motifs (GSP, GQP, GEP, and GSQ) and incorporating integrin-binding seq...

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Literature Corpus work
a691f1e1-f5cb-55ab-b976-187dfed02bc1
DOI
10.21203/rs.3.rs-8516546/v1
Open publication

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