Article
Inactivation of the extracytoplasmic function sigma factor Sig6 stimulates avermectin production in Streptomyces avermitilis.
Biotechnology letters - 1 Oct 2011
Jiang Libin, Liu Yanping, Wang Pan, Wen Ying, Song Yuan, Chen Zhi, Li Jilun
Abstract excerpt
The role of the extracytoplasmic function (ECF) σ factor Sig6 (SAV663) in avermectin production by Streptomyces avermitilis was investigated by gene-deletion, complementation and over-expression experiments. Inactivation of Sig6 had no major effect on growth, stress responses, or morphology. Avermectin yield was increased 2- to 2.7-fold (~680 μg/ml) relative to the wild-type strain by deletion of the sig6 gene,...
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