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Article

Dual positive feedback regulation of protein degradation of an extra-cytoplasmic function σ factor for cell differentiation in Streptomyces coelicolor.

The Journal of biological chemistry - 25 Oct 2013

Mao Xu-Ming, Sun Ning, Wang Feng, Luo Shuai, Zhou Zhan, Feng Wei-Hong, Huang Fang-Liang, Li Yong-Quan

Abstract excerpt

Here we report that in Streptomyces coelicolor, the protein stability of an ECF σ factor SigT, which is involved in the negative regulation of cell differentiation, was completely dependent on its cognate anti-σ factor RstA. The degradation of RstA caused a ClpP/SsrA-dependent degradation of SigT during cell differentiation. This was consistent with the delayed morphological development or secondary metabolism in...

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Identifiers

PMID: 24014034
DOI: 10.1074/jbc.M113.491498
PMCID: PMC3829432

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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