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Possible linkages between the inner and outer cellular states of human induced pluripotent stem cells

20 Jun 2011

Abstract excerpt

BACKGROUND: Human iPS cells (hiPSCs) have attracted considerable attention for applications to drug screening and analyses of disease mechanisms, and even as next generation materials for regenerative medicine. Genetic reprogramming of human somatic cells to a pluripotent state was first achieved by the ectopic expression of four factors (Sox2, Oct4, Klf4 and c-Myc), using a retrovirus. Subsequently, this method...

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PMID: 21689476
DOI: 10.1186/1752-0509-5-s1-s17

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