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Article

Genetic disruption of the PI3K regulatory subunits, p85α, p55α, and p50α, normalizes mutant PTPN11-induced hypersensitivity to GM-CSF.

Haematologica - 1 Jul 2012

Goodwin Charles B, Yang Zhenyun, Yin Fuqin, Yu Menggang, Chan Rebecca J

Abstract excerpt

Juvenile myelomonocytic leukemia is a lethal disease of children characterized by hypersensitivity of hematopoietic progenitors to granulocyte macrophage-colony stimulating factor. Mutations in PTPN11, the gene encoding the protein tyrosine phosphatase Shp2, are common in juvenile myelomonocytic leukemia and induce hyperactivation of the phosphoinositide-3-kinase pathway. We found that genetic disruption of...

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Share to Class Ia Phosphatidylinositol 3-Kinase
Share to Extracellular Signal-Regulated MAP Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Farnesyltranstransferase

Share to Granulocyte-Macrophage Colony-Stimulating Factor

Share to Leukemia, Myelomonocytic, Juvenile

Share to Phosphoinositide-3 Kinase Inhibitors

Share to Protein Tyrosine Phosphatase, Non-Receptor Type 11

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Source

Open in PubMed Open full text

Identifiers

PMID: 22315502
DOI: 10.3324/haematol.2011.046896
PMCID: PMC3396676

Genes

PTPN11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Genetic disruption of the PI3K regulatory subunits, p85α, p55α, and p50α, normalizes mutant PTPN11-induced hypersensitivity to GM-CSF.PMID 22315502Read ↗

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