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Article

Chronic restraint stress attenuates p53 function and promotes tumorigenesis

16 Apr 2012

Abstract excerpt

Epidemiological studies strongly suggest that chronic psychological stress promotes tumorigenesis. However, its direct link in vivo and the underlying mechanisms that cause this remain unclear. This study provides direct evidence that chronic stress promotes tumorigenesis in vivo; chronic restraint, a well-established mouse model to induce chronic stress, greatly promotes ionizing radiation (IR)-induced...

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Identifiers

PMID: 22509031
DOI: 10.1073/pnas.1203930109

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