Article

RNAi Screening in Primary Human Breast Biopsies Identifies Mitochondrial Glutamate Flux as A Metabolic Vulnerability in Locally Advanced Breast Cancer

2021-03-03

Abstract excerpt

<title>Abstract</title> <p><bold>Background:</bold> Breast cancer (BC) is a leading cause of death in women[1]. Women with Locally Advanced Breast Cancer (LABC) have high risk disease with either large primary breast tumours and/or lymph node involvement. While neoadjuvant chemotherapy eradicates breast cancer in approximately one-third of cases prior to surgery, almost 70% of patients have residual disease and m...

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Literature Corpus work: 02ff8f8f-e64c-580f-b7c4-a067fbd57e5e
DOI: 10.21203/rs.3.rs-260480/v1

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