Article
A novel FK-506-binding-like protein that lacks peptidyl-prolyl isomerase activity is involved in intracellular infection and in vivo virulence of Burkholderia pseudomallei.
Microbiology (Reading, England) - 1 Sept 2011
Norville Isobel H, Breitbach Katrin, Eske-Pogodda Kristin, Harmer Nicholas J, Sarkar-Tyson Mitali, Titball Richard W, Steinmetz Ivo
Abstract excerpt
Burkholderia pseudomallei is a facultative intracellular bacterial pathogen causing melioidosis, an often fatal infectious disease that is endemic in several tropical and subtropical areas around the world. We previously described a Ptk2 cell-based plaque assay screening system of B. pseudomallei transposon mutants that led to the identification of several novel virulence determinants. Using this approach we...
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