Article
Mitochondrial DNA lineages of African origin confer susceptibility to primary open-angle glaucoma in Saudi patients.
Molecular vision - 1 Jan 2011
Abu-Amero Khaled K, González Ana M, Osman Essam A, Larruga José M, Cabrera Vicente M, Al-Obeidan Saleh A
Abstract excerpt
PURPOSE: We previously reported that certain mitochondrial DNA (mtDNA) polymorphisms in the coding region may be involved in the pathogenesis for primary open-angle-glaucoma (POAG). This encouraged us to extend our work and assess whether mtDNA diagnostic polymorphisms, defining geographically structured haplogroups, could be associated with the development of POAG. METHODS: We sequenced the mtDNA regulatory...
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