Article
Mitochondrial sequence variation in African-American primary open-angle glaucoma patients.
PloS one - 1 Jan 2013
Collins David W, Gudiseva Harini V, Trachtman Benjamin T, Jerrehian Matthew, Gorry Thomasine, Merritt William T, Rhodes Allison L, Sankar Prithvi S, Regina Meredith, Miller-Ellis Eydie, O'Brien Joan M
Abstract excerpt
Primary open-angle glaucoma (POAG) is a major cause of blindness and results from irreversible retinal ganglion cell damage and optic nerve degeneration. In the United States, POAG is most prevalent in African-Americans. Mitochondrial genetics and dysfunction have been implicated in POAG, and potentially pathogenic sequence variations, in particular novel transversional base substitutions, are reportedly common...
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