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Article

Factor H-related protein 1 neutralizes anti-factor H autoantibodies in autoimmune hemolytic uremic syndrome.

Kidney international - 1 Aug 2011

Strobel Stefanie, Abarrategui-Garrido Cynthia, Fariza-Requejo Elena, Seeberger Harald, Sánchez-Corral Pilar, Józsi Mihály

Abstract excerpt

The autoimmune form of atypical hemolytic uremic syndrome (HUS) is characterized by circulating autoantibodies against the complement regulator factor H, and is often associated with deficiency of the factor H-related proteins CFHR1 and CFHR3. Here we studied whether anti-factor H autoantibodies crossreact with CFHR1, and determined functional consequences of this. In ELISA, anti-factor H immunoglobulin G (IgG)...

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Topics

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Share to Antibody Specificity
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Atypical Hemolytic Uremic Syndrome

Share to Complement C3b Inactivator Proteins

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Source

Identifiers

PMID: 21677636
DOI: 10.1038/ki.2011.152

Genes

CFHR1
CFHR3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Factor H-related protein 1 neutralizes anti-factor H autoantibodies in autoimmune hemolytic uremic syndrome.PMID 21677636Read ↗

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