Article
[Early diagnosis of retinoblastoma: usefulness of searching for RB1 gene mutations].
Medicina clinica - 17 Mar 2001
Nájera C, Sánchez F, Mateu E, Prieto F, Beneyto M
Abstract excerpt
BACKGROUND: Retinoblastoma, the intraocular malignancy most common in children,occurs in both familial and sporadic (bilateral or unilateral). Hereditary predisposition is caused by a germ-line mutation while non-hereditary is due to two somatic mutations in a retinal cell. This work was carried out in order to analyse genetically, the high number of families with some affected member and to go deep into the...
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