Article
Myelin basic protein as a novel genetic risk factor in rheumatoid arthritis--a genome-wide study combined with immunological analyses.
PloS one - 1 Jan 2011
Terao Chikashi, Ohmura Koichiro, Katayama Masaki, Takahashi Meiko, Kokubo Miki, Diop Gora, Toda Yoshinobu, Yamamoto Natsuki, Shinkura Reiko, Shimizu Masakazu, Gut Ivo, Heath Simon, Melchers Inga, Manabe Toshiaki, Lathrop Mark, Mimori Tsuneyo, Yamada Ryo, Matsuda Fumihiko
Abstract excerpt
Rheumatoid arthritis (RA) is a major cause of adult chronic inflammatory arthritis and a typical complex trait. Although several genetic determinants have been identified, they account for only a part of the genetic susceptibility. We conducted a genome-wide association study of RA in Japanese using 225,079 SNPs genotyped in 990 cases and 1,236 controls from two independent collections (658 cases and 934 controls...
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