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Prostaglandins Regulate Surfactant Protein A (SP-A) Gene Expression in Human Fetal Lung<i>in Vitro</i>*

1 Sept 1990

Abstract excerpt

We previously have observed that dexamethasone has a biphasic effect on surfactant protein A (SP-A) mRNA levels in human fetal lung in vitro. At concentrations of 10(-10)-10(-9) M, dexamethasone increases the levels of SP-A mRNA, whereas, at concentrations greater than 10(-8) M, the steroid is markedly inhibitory. In studies to define the molecular mechanisms for these effects, we observed that dexamethasone...

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PMID: 2167205
DOI: 10.1210/endo-127-3-1105

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