Article
Surfactant protein-A (SP-A) selectively inhibits prostaglandin F2alpha (PGF2alpha) production in term decidua: implications for the onset of labor.
The Journal of clinical endocrinology and metabolism - 1 Apr 2011
Snegovskikh Victoria V, Bhandari Vineet, Wright Jo Rae, Tadesse Serkalem, Morgan Thomas, Macneill Colin, Foyouzi Nastaran, Park Joong Shin, Wang Yuguang, Norwitz Errol R
Abstract excerpt
CONTEXT: Labor is characterized by "decidual activation" with production of inflammatory mediators. Recent data suggest that surfactant protein-A (SP-A) may be critical to the onset of labor in mice. Whether this is also true in humans is unclear. OBJECTIVES: The aim was to investigate: 1) the expression of SP-A at the maternal-fetal interface; 2) the effect of SP-A on the production of inflammatory mediators by...
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