Article
Renal cell carcinoma primary cultures maintain genomic and phenotypic profile of parental tumor tissues.
BMC cancer - 13 Jun 2011
Cifola Ingrid, Bianchi Cristina, Mangano Eleonora, Bombelli Silvia, Frascati Fabio, Fasoli Ester, Ferrero Stefano, Di Stefano Vitalba, Zipeto Maria A, Magni Fulvio, Signorini Stefano, Battaglia Cristina, Perego Roberto A
Abstract excerpt
BACKGROUND: Clear cell renal cell carcinoma (ccRCC) is characterized by recurrent copy number alterations (CNAs) and loss of heterozygosity (LOH), which may have potential diagnostic and prognostic applications. Here, we explored whether ccRCC primary cultures, established from surgical tumor spe...
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