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Article

ER, HER2, and TOP2A expression in primary tumor, synchronous axillary nodes, and asynchronous metastases in breast cancer.

Breast cancer research and treatment - 1 Apr 2012

Jensen Jeanette Dupont, Knoop Ann, Ewertz Marianne, Laenkholm Anne-Vibeke

Abstract excerpt

At recurrence of breast cancer, the therapeutic target is the metastases. However, it is current practice to base the choice of systemic treatment on the biomarker profile of the primary tumor. In the present study, confirmatory biopsies were obtained from suspected metastatic lesions and compared with the primary tumors with respect to ER, HER2, and TOP2A. In the prospective tissue-collection study, 81 patients...

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Source

Identifiers

PMID: 21667123
DOI: 10.1007/s10549-011-1610-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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