Article
Population genetics of GYPB and association study between GYPB*S/s polymorphism and susceptibility to P. falciparum infection in the Brazilian Amazon.
PloS one - 24 Jan 2011
Tarazona-Santos Eduardo, Castilho Lilian, Amaral Daphne R T, Costa Daiane C, Furlani Natália G, Zuccherato Luciana W, Machado Moara, Reid Marion E, Zalis Mariano G, Rossit Andréa R, Santos Sidney E B, Machado Ricardo L, Lustigman Sara
Abstract excerpt
BACKGROUND: Merozoites of Plasmodium falciparum invade through several pathways using different RBC receptors. Field isolates appear to use a greater variability of these receptors than laboratory isolates. Brazilian field isolates were shown to mostly utilize glycophorin A-independent invasion pathways via glycophorin B (GPB) and/or other receptors. The Brazilian population exhibits extensive polymorphism in...
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