A single-nucleotide polymorphism in tumor suppressor gene SEL1L as a predictive and prognostic marker for pancreatic ductal adenocarcinoma in Caucasians.

doi:10.1002/mc.20808

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Article

A single-nucleotide polymorphism in tumor suppressor gene SEL1L as a predictive and prognostic marker for pancreatic ductal adenocarcinoma in Caucasians.

Molecular carcinogenesis - 1 May 2012

Liu Qian, Chen Jinyun, Mai Billy, Amos Christopher, Killary Ann M, Sen Subrata, Wei Chongjuan, Frazier Marsha L

Abstract excerpt

SEL1L is a putative tumor suppressor gene that is frequently down-regulated in pancreatic ductal adenocarcinoma (PDA). A single-nucleotide polymorphism (SNP) rs12435998 in intron3 of SEL1L has previously been reported to be associated with susceptibility to Alzheimer's disease. We hypothesized that this SNP may influence clinical outcomes of patients with PDA. We analyzed DNA samples from 497 Caucasian patients...

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PMID: 21656579
DOI: 10.1002/mc.20808
PMCID: PMC3780592

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