Article
Increased basal intracellular signaling patterns do not correlate with JAK2 genotype in human myeloproliferative neoplasms.
Blood - 11 Aug 2011
Anand Shubha, Stedham Frances, Gudgin Emma, Campbell Peter, Beer Philip, Green Anthony R, Huntly Brian J P
Abstract excerpt
Myeloproliferative neoplasms (MPNs) are associated with recurrent activating mutations of signaling proteins such as Janus kinase 2 (JAK2). However, the actual downstream signaling events and how these alter myeloid homeostasis are poorly understood. We developed an assay to measure basal levels of phosphorylated signaling intermediates by flow cytometry during myeloid differentiation in MPN patients. Our study...
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