Article
Preferential nuclear accumulation of JAK2V617F in CD34+ but not in granulocytic, megakaryocytic, or erythroid cells of patients with Philadelphia-negative myeloproliferative neoplasia.
Blood - 23 Dec 2010
Rinaldi Ciro R, Rinaldi Paola, Alagia Adele, Gemei Marica, Esposito Nicola, Formiggini Fabio, Martinelli Vincenzo, Senyuk Vitalyi, Nucifora Giuseppina, Pane Fabrizio
Abstract excerpt
Recently, Dawson et al identified a previously unrecognized nuclear role of JAK2 in the phosphorylation of histone H3 in hematopoietic cell lines. We searched nuclear JAK2 in total bone marrow (BM) cells and in 4 sorted BM cell populations (CD34(+), CD15(+), CD41(+), and CD71(+)) of 10 myeloproliferative neoplasia (MPN) patients with JAK2V617F mutation and 5 patients with wild-type JAK2 MPN. Confocal...
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