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Article

Estrogen regulation of the dopamine-activated GIRK channel in pituitary lactotrophs: implications for regulation of prolactin release during the estrous cycle.

American journal of physiology. Regulatory, integrative and comparative physiology - 1 Sept 2011

Christensen Heather R, Zeng Qinghua, Murawsky Michael K, Gregerson Karen A

Abstract excerpt

Prolactin (PRL), synthesized and secreted from lactotrophs of the anterior pituitary gland, is tonically inhibited by hypothalamic dopamine (DA) throughout the female reproductive (estrous) cycle. Our laboratory has shown that DA hyperpolarizes these cells by activating G protein-coupled inwardly rectifying K(+) (GIRK) channels; however, this response is only observed on proestrus. While the cellular mechanisms...

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PMID: 21653876
DOI: 10.1152/ajpregu.00138.2011
PMCID: PMC3290005

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PRL

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