Article
Mitoxantrone inhibits HIF-1α expression in a topoisomerase II-independent pathway.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Aug 2011
Toh Yng-Miin, Li Tsai-Kun
Abstract excerpt
PURPOSE: Solid tumors encounter a growth-limiting hypoxic microenvironment as they develop. Hypoxia-inducible factors (HIF) play important roles in hypoxia-associated tumor development and therapeutic resistance. Targeting the HIF pathway (especially HIF-1α) represents a promising cancer treatment strategy. Here, we report a novel class of HIF-1α inhibitors and the possible molecular basis of inhibition....
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