Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

An Original Deal for New Molecule: Reversal of Efflux Pump Activity, A Rational Strategy to Combat Gram-Negative Resistant Bacteria

1 Jun 2011

Abstract excerpt

The worldwide dissemination of «multi-drug resistant» (MDR) pathogens has severely reduced the efficacy of our antibiotic arsenal and increased the frequency of therapeutic failure. MDR bacteria over-express efflux pumps and this active mechanism can extrude all classes of antibiotics from the cell. It is necessary to clearly decipher the genetic, structural and functional aspects of this transport system in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibiotic Resistance in Bacteria
Share to Tuberculosis Research and Epidemiology

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 21651484
DOI: 10.2174/092986711796150469

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

An Original Deal for New Molecule: Reversal of Efflux Pump Activity, A Rational Strategy to Combat Gram-Negative Resistant BacteriaPMID 21651484Read ↗

Extending the Potency and Lifespan of Antibiotics: Inhibitors of Gram-Negative Bacterial Efflux PumpsSemantic proximity Read ↗

Efflux Pumps: Their Role in Antibacterial Drug DiscoverySemantic proximity Read ↗

Recent advances toward a molecular mechanism of efflux pump inhibitionSemantic proximity Read ↗

New Roads Leading to Old Destinations: Efflux Pumps as Targets to Reverse Multidrug Resistance in BacteriaSemantic proximity Read ↗

Antibiotic efflux pumps in Gram-negative bacteria: the inhibitor response strategySemantic proximity Read ↗

Update on the Discovery of Efflux Pump Inhibitors against Critical Priority Gram-Negative BacteriaSemantic proximity Read ↗

Efflux-mediated Multidrug Resistance in Critical Gram-negative Bacteria and Natural Efflux Pump InhibitorsSemantic proximity Read ↗

Structure and function of efflux pumps that confer resistance to drugsSemantic proximity Read ↗

Multidrug efflux pumps and their role in antibiotic and antiseptic resistance: a pharmacodynamic perspectiveSemantic proximity Read ↗

Efflux-Mediated Resistance in Enterobacteriaceae: Recent Advances and Ongoing Challenges to Inhibit Bacterial Efflux PumpsSemantic proximity Read ↗

Efflux Pumps of Gram-Negative Bacteria, a New Target for New MoleculesSemantic proximity Read ↗

Inhibitors of Multidrug Resistant Efflux Systems in BacteriaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.