Article
Novel method for differentiation between Trastuzumab and host adaptive response.
Molecular immunology - 1 Sept 2011
Denisova Galina, Jenkins Kristina, Evelegh Carole, Bramson Jonathan
Abstract excerpt
Humoral immune response to human epidermal growth factor receptor 2 (HER-2/neu or ErbB-2) has been detected in sera of breast cancer patients and shown to be an appropriate prognostic marker (Taylor et al., 2007). However, since Trastuzumab (Herceptin) is a widely used monoclonal antibody as cancer therapy agent for tumors over-expressing HER-2, there is a need for an efficient way to detect host-generated...
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