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Protection against mammary tumor growth by vaccination with full-length, modified humanErbB-2 DNA

31 May 1999

Abstract excerpt

ErbB-2 is overexpressed in several human cancers and conveys a transforming activity that is dependent on tyrosine kinase activity. Antibodies and T cells to ErbB-2 have been isolated from cancer patients, indicating ErbB-2 as a potential target of active vaccination. In this study, 3 mutant ErbB-2 DNA constructs encoding full-length, ErbB-2 proteins were tested as tumor vaccines. To eliminate tyrosine kinase...

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PMID: 10328228
DOI: 10.1002/(sici)1097-0215(19990531)81:5<748::aid-ijc14>3.0.co;2-6

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