Article
Role of SEREX-defined immunogenic wild-type cellular molecules in the development of tumor-specific immunity.
Proceedings of the National Academy of Sciences of the United States of America - 4 Dec 2001
Nishikawa H, Tanida K, Ikeda H, Sakakura M, Miyahara Y, Aota T, Mukai K, Watanabe M, Kuribayashi K, Old L J, Shiku H
Abstract excerpt
Recognition of altered self-antigens in tumor cells by lymphocytes forms the basis for antitumor immune responses. The effector cells in most experimental tumor systems are CD8(+) T cells that recognize MHC class I binding peptides derived from molecules with altered expression in tumor cells. Although the need for CD4(+) helper T cells in regulating CD8(+) T cells has been documented, their target epitopes and...
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