Article
Characterization of killer immunoglobulin-like receptor genetics and comprehensive genotyping by pyrosequencing in rhesus macaques.
BMC genomics - 7 Jun 2011
Moreland Anna J, Guethlein Lisbeth A, Reeves R Keith, Broman Karl W, Johnson R Paul, Parham Peter, O'Connor David H, Bimber Benjamin N
Abstract excerpt
BACKGROUND: Human killer immunoglobulin-like receptors (KIRs) play a critical role in governing the immune response to neoplastic and infectious disease. Rhesus macaques serve as important animal models for many human diseases in which KIRs are implicated; however, the study of KIR activity in this model is hindered by incomplete characterization of KIR genetics. RESULTS: Here we present a characterization of KIR...
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