Article
Family association study between INSR gene polymorphisms and PCOS in Han Chinese.
Reproductive biology and endocrinology : RB&E - 6 Jun 2011
Xu Xinghua, Zhao Han, Shi Yuhua, You Li, Bian Yuehong, Zhao Yueran, Chen Zi-Jiang
Abstract excerpt
BACKGROUND: Polycystic ovary syndrome (PCOS) is a complex disease having both genetic and environmental components. Candidate genes with insulin metabolism have been hypothesized to be involved in the etiology of this syndrome. In the present study, we investigated the genetic association between polymorphisms in the insulin receptor (INSR) gene and PCOS. METHODS: A total of 260 family trios were recruited and...
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