Article
IDH mutation status impact on in vivo hypoxia biomarkers expression: new insights from a clinical, nuclear imaging and immunohistochemical study in 33 glioma patients.
Journal of neuro-oncology - 1 Dec 2011
Metellus Philippe, Colin Carole, Taieb David, Guedj Eric, Nanni-Metellus Isabelle, de Paula Andre Maues, Colavolpe Cécile, Fuentes Stephane, Dufour Henry, Barrie Marylin, Chinot Olivier, Ouafik L'houcine, Figarella-Branger Dominique
Abstract excerpt
Mutations in the gene encoding isocitrate dehydrogenase enzyme isoforms 1 (IDH1) and 2 (IDH2) have recently been identified in a large proportion of glial tumors of the CNS, but their mechanistic role in tumor development remains unclear. Here, we assessed the actual impact of IDH1 and IDH2 mutations in patients harboring WHO grade II and III gliomas. We sequenced IDH1 at codon 132 and IDH2 at codon 172 in 33...
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