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Article

Differential effect of polymorphisms of CMPK1 and RRM1 on survival in advanced non-small cell lung cancer patients treated with gemcitabine or taxane/cisplatinum.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 Aug 2011

Ryu Jeong-Seon, Shin Eun-Soon, Nam Hae-Seong, Yi Hyeon-Gyu, Cho Jae-Hwa, Kim Chul-Soo, Kim Hyun-Jung, Lee Jong-Eun

Abstract excerpt

INTRODUCTION: To determine whether genetic variations in CMPK1 or RRM1, which impact the pharmacodynamics of gemcitabine, differentially affect the outcomes of non-small cell lung cancer (NSCLC) patients treated with gemcitabine or taxane/cisplatinum. METHODS: We conducted retrospective study evaluating the associations between overall survival in 298 NSCLC patients at stages IIIA/IIIB (140) and IV (158), treated...

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Identifiers

PMID: 21642870
DOI: 10.1097/JTO.0b013e3182208e26

Genes

CMPK1
RRM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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