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Article

RRM1 single nucleotide polymorphism -37C-->A correlates with progression-free survival in NSCLC patients after gemcitabine-based chemotherapy.

Journal of hematology & oncology - 13 Mar 2010

Dong Song, Guo Ai-Lin, Chen Zhi-Hong, Wang Zhen, Zhang Xu-Chao, Huang Ying, Xie Zhi, Yan Hong-Hong, Cheng Hua, Wu Yi-Long

Abstract excerpt

BACKGROUND: The ribonucleotide reductase M1 (RRM1) gene encodes the regulatory subunit of ribonucleotide reductase, the molecular target of gemcitabine. The overexpression of RRM1 mRNA in tumor tissues is reported to be associated with gemcitabine resistance. Thus, single nucleotide polymorphisms (SNPs) of the RRM1 gene are potential biomarkers of the response to gemcitabine chemotherapy. We investigated whether...

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Source

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Identifiers

PMID: 20226083
DOI: 10.1186/1756-8722-3-10
PMCID: PMC2855513

Genes

RRM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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