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Predicting chemosensitivity to gemcitabine and cisplatin based on gene polymorphisms and mRNA expression in non-small-cell lung cancer cells.

Pharmacogenomics - 1 Jan 2015

Meng Xiangning, Wang Geng, Guan Rongwei, Jia Xueyuan, Gao Wei, Wu Jie, Yu Jingcui, Liu Peng, Yu Yang, Sun Wenjing, Dong Haiying, Fu Songbin

Abstract excerpt

AIM: We used a panel of 17 non-small-cell lung cancer cell lines to investigate whether the presence of polymorphisms in the RRM1, ERCC1, ABCB1 and MTHFR genes and alterations in their mRNA expression can affect the in vitro chemosensitivity to cisplatin and gemcitabine. MATERIALS & METHODS: Polymorphisms in these genes were evaluated by direct sequencing. mRNA expression levels were assessed by realtime PCR. In...

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Share to Antineoplastic Combined Chemotherapy Protocols
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25560468
DOI: 10.2217/pgs.14.159

Genes

ABCB1
MTHFR
RRM1
ERCC1

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