Article
Genetic contribution for non-syndromic cleft lip with or without cleft palate (NS CL/P) in different regions of Brazil and implications for association studies.
American journal of medical genetics. Part A - 1 Jul 2011
Brito Luciano A, Cruz Lucas A, Rocha Kátia M, Barbara Ligia K, Silva Camila B F, Bueno Daniela F, Aguena Meire, Bertola Débora R, Franco Diogo, Costa André M, Alonso Nivaldo, Otto Paulo A, Passos-Bueno Maria Rita
Abstract excerpt
Non-syndromic cleft lip with or without cleft palate (NS CL/P) is a complex disease in which heritability estimates vary widely depending on the population studied. To evaluate the importance of genetic contribution to NS CL/P in the Brazilian population, we conducted a study with 1,042 families from five different locations (Santarém, Fortaleza, Barbalha, Maceió, and Rio de Janeiro). We also evaluated the role...
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