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Article

Contribution of the 80s loop of HIV-1 protease to the multidrug-resistance mechanism: crystallographic study of MDR769 HIV-1 protease variants.

Acta crystallographica. Section D, Biological crystallography - 1 Jun 2011

Yedidi Ravikiran S, Proteasa Georghe, Martinez Jorge L, Vickrey John F, Martin Philip D, Wawrzak Zdzislaw, Liu Zhigang, Kovari Iulia A, Kovari Ladislau C

Abstract excerpt

The flexible flaps and the 80s loops (Pro79-Ile84) of HIV-1 protease are crucial in inhibitor binding. Previously, it was reported that the crystal structure of multidrug-resistant 769 (MDR769) HIV-1 protease shows a wide-open conformation of the flaps owing to conformational rigidity acquired by the accumulation of mutations. In the current study, the effect of mutations on the conformation of the 80s loop of...

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Share to Crystallography, X-Ray
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21636892
DOI: 10.1107/S0907444911011541
PMCID: PMC3107050

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