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Article

The higher barrier of darunavir and tipranavir resistance for HIV-1 protease.

Biochemical and biophysical research communications - 9 Sept 2011

Wang Yong, Liu Zhigang, Brunzelle Joseph S, Kovari Iulia A, Dewdney Tamaria G, Reiter Samuel J, Kovari Ladislau C

Abstract excerpt

Darunavir and tipranavir are two inhibitors that are active against multi-drug resistant (MDR) HIV-1 protease variants. In this study, the invitro inhibitory efficacy was tested against a MDR HIV-1 protease variant, MDR 769 82T, containing the drug resistance mutations of 46L/54V/82T/84V/90M. Crystallographic and enzymatic studies were performed to examine the mechanism of resistance and the relative maintenance...

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Identifiers

PMID: 21871444
DOI: 10.1016/j.bbrc.2011.08.045
PMCID: PMC3188455

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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