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Article

Effects of the V82A and I54V mutations on the dynamics and ligand binding properties of HIV-1 protease.

Journal of molecular modeling - 1 Oct 2010

Dirauf Pia, Meiselbach Heike, Sticht Heinrich

Abstract excerpt

A major problem in the antiretroviral treatment of HIV-infections with protease-inhibitors is the emergence of resistance, resulting from the occurrence of distinct mutations within the protease molecule. In the present work we investigated the structural properties of a triple mutant (I54V-V82A-L90M) and a double mutant (V82A-L90M) that both confer strong resistance to ritonavir (RTV), but not to amprenavir...

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Identifiers

PMID: 20195662
DOI: 10.1007/s00894-010-0677-9

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