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Article

"Wide-open" 1.3 A structure of a multidrug-resistant HIV-1 protease as a drug target.

Structure (London, England : 1993) - 1 Dec 2005

Martin Philip, Vickrey John F, Proteasa Gheorghe, Jimenez Yurytzy L, Wawrzak Zdzislaw, Winters Mark A, Merigan Thomas C, Kovari Ladislau C

Abstract excerpt

This report examines structural changes in a highly mutated, clinical multidrug-resistant HIV-1 protease, and the crystal structure has been solved to 1.3 A resolution in the absence of any inhibitor. This protease variant contains codon mutations at positions 10, 36, 46, 54, 62, 63, 71, 82, 84, and 90 that confer resistance to protease inhibitors. Major differences between the wild-type and the variant include a...

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Identifiers

PMID: 16338417
DOI: 10.1016/j.str.2005.11.005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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