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Article

Drug Resistance Mutation L76V Alters Nonpolar Interactions at the Flap–Core Interface of HIV-1 Protease

27 Sept 2018

Abstract excerpt

High Resolution Image Download MS PowerPoint Slide Four HIV-1 protease (PR) inhibitors, clinical inhibitors lopinavir and tipranavir, and two investigational compounds 4 and 5, were studied for their effect on the structure and activity of PR with drug-resistant mutation L76V (PR L76V ). Compound 5 exhibited the best K i value of 1.9 nM for PR L76V, whereas the other three inhibitors had K i values of 4.5–7.6 nM,...

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Identifiers

PMID: 30288468
DOI: 10.1021/acsomega.8b01683

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