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Article

Conserved hydrogen bonds and water molecules in MDR HIV-1 protease substrate complexes.

Biochemical and biophysical research communications - 18 Jan 2013

Liu Zhigang, Wang Yong, Yedidi Ravikiran S, Dewdney Tamaria G, Reiter Samuel J, Brunzelle Joseph S, Kovari Iulia A, Kovari Ladislau C

Abstract excerpt

The success of highly active antiretroviral therapy (HAART) in anti-HIV therapy is severely compromised by the rapidly developing drug resistance. HIV-1 protease inhibitors, part of HAART, are losing their potency and efficacy in inhibiting the target. Multi-drug resistant (MDR) 769 HIV-1 protease (resistant mutations at residues 10, 36, 46, 54, 62, 63, 71, 82, 84, 90) was selected for the present study to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23261453
DOI: 10.1016/j.bbrc.2012.12.045
PMCID: PMC4520401

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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