Article
Novel ways to target brain tumour metabolism.
Expert opinion on therapeutic targets - 1 Oct 2011
Stieber Daniel, Abdul Rahim Siti A, Niclou Simone P
Abstract excerpt
INTRODUCTION: Glioblastoma remains a highly aggressive primary brain cancer with very poor prognosis. The detection of mutations in the metabolic enzyme isocitrate dehydrogenase in gliomas, has broadened our view of tumourigenic mechanisms. Together with renewed awareness of tumour-specific energy metabolism, research is pointed towards novel ways for targeting brain cancer. AREAS COVERED: This paper reviews...
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