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Article

Isolation of the Candida albicans histidinol dehydrogenase (HIS4) gene and characterization of a histidine auxotroph.

Journal of bacteriology - 1 Jul 1990

Altboum Z, Gottlieb S, Lebens G A, Polacheck I, Segal E

Abstract excerpt

Genetic studies were done with Candida albicans CBS 562. Various auxotrophs were isolated following mutagenesis with N-methyl-N'-nitro-N-nitrosoguanidine. SAG5 (his4C), a stable histidine auxotroph defective in histidinol dehydrogenase activity, was characterized and chosen for further molecular studies. Therefore, the C. albicans HIS4 gene was isolated. The gene was obtained from a genomic library of the...

Topics

Alcohol Oxidoreductases
Aminohydrolases
Candida albicans
Chromosomes, Fungal
DNA, Fungal
Genes, Fungal
Genetic Complementation Test
Genotype
Histidine
Mutation
Nucleic Acid Hybridization

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phenotype

Plasmids

Pyrophosphatases

Restriction Mapping

Saccharomyces cerevisiae

Source

Open in PubMed Open full text

Identifiers

PMID: 2163392
DOI: 10.1128/jb.172.7.3898-3904.1990
PMCID: PMC213371

Genes

CBS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2163392-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Click a neighbor to travelStep 1 · 12 closest

Isolation of the Candida albicans histidinol dehydrogenase (HIS4) gene and characterization of a histidine auxotroph.PMID 2163392Read ↗

A single SNP, G929T (Gly310Val), determines the presence of a functional and a non-functional allele of HIS4 in Candida albicans SC5314: detection of the non-functional allele in laboratory strains.Semantic proximity Read ↗

Cloning and functional verification of the Candida milleri HIS3 gene encoding imidazoleglycerol phosphate dehydratase.Semantic proximity Read ↗

Regulation of the Aspergillus nidulans hisB gene by histidine starvation.Semantic proximity Read ↗

Cloning and sequence of a 3.835 kbp DNA fragment containing the HIS4 gene and a fragment of a PEX5-like gene from Candida albicans.Semantic proximity Read ↗

HisB as novel selection marker for gene targeting approaches in Aspergillus niger.Semantic proximity Read ↗

Molecular characterization and expression study of a histidine auxotrophic mutant (his1-) of Nicotiana plumbaginifolia.Semantic proximity Read ↗

Characterization of the histidine mutants of Kluyveromyces lactis.Semantic proximity Read ↗

[Cloning and inactivation of a chromosomal copy of the imidazole glycerophosphate dehydratase (HIS) gene from Hansenula polymorpha].Semantic proximity Read ↗

Cloning of mycobacterial histidine synthesis genes by complementation of a Mycobacterium smegmatis auxotroph.Semantic proximity Read ↗

The Candida albicans CHS4 gene complements a Saccharomyces cerevisiae skt5/chs4 mutation and is involved in chitin biosynthesis.Semantic proximity Read ↗

Isolation of auxotrophic mutants of the methylotrophic yeast Candida boidinii and determination of its ploidy.Semantic proximity Read ↗

Histidinol phosphate phosphatase, catalyzing the penultimate step of the histidine biosynthesis pathway, is encoded by ytvP (hisJ) in Bacillus subtilis.Semantic proximity Read ↗

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