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Article

Host Alternation Is Necessary to Maintain the Genome Stability of Rift Valley Fever Virus

24 May 2011

Abstract excerpt

BACKGROUND: Most arthropod-borne viruses (arboviruses) are RNA viruses, which are maintained in nature by replication cycles that alternate between arthropod and vertebrate hosts. Arboviruses appear to experience lower rates of evolution than RNA viruses that replicate in a single host. This genetic stability is assumed to result from a fitness trade-off imposed by host alternation, which constrains arbovirus...

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PMID: 21629727
DOI: 10.1371/journal.pntd.0001156

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