Article
Emergence of mammalian cell-adapted vesicular stomatitis virus from persistent infections of insect vector cells.
Journal of virology - 1 Jun 2007
Novella Isabel S, Ebendick-Corpus Bonnie E, Zárate Selene, Miller Eric L
Abstract excerpt
Arboviruses (arthropod-borne viruses) represent quintessential generalists, with the ability to infect and perform well in multiple hosts. However, antagonistic pleiotropy imposed a cost during the adaptation to persistent replication of vesicular stomatitis virus in sand fly cells and resulted in strains that initially replicated poorly in hamster cells, even when the virus was allowed to replicate periodically...
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