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Article

Genetic anticipation in Swedish Lynch syndrome families.

PLoS genetics - 1 Oct 2017

von Salomé Jenny, Boonstra Philip S, Karimi Masoud, Silander Gustav, Stenmark-Askmalm Marie, Gebre-Medhin Samuel, Aravidis Christos, Nilbert Mef, Lindblom Annika, Lagerstedt-Robinson Kristina

Abstract excerpt

Among hereditary colorectal cancer predisposing syndromes, Lynch syndrome (LS) caused by mutations in DNA mismatch repair genes MLH1, MSH2, MSH6 or PMS2 is the most common. Patients with LS have an increased risk of early onset colon and endometrial cancer, but also other tumors that generally have an earlier onset compared to the general population. However, age at first primary cancer varies within families and...

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Source

Open in PubMed Open full text

Identifiers

PMID: 29088233
DOI: 10.1371/journal.pgen.1007012
PMCID: PMC5681299

Genes

MLH1
MSH2
PMS2
MSH6
EPCAM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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