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Personalized risk estimates of advanced neoplasia development in individuals with a family history of colorectal cancer.

Familial cancer - 14 May 2026

Greuter Marjolein J E, Akwiwu Eddymurphy U, Hennink Simone D, Bisseling Tanya M, Spanier Marcel B W, Nagtegaal Iris D, Canfell Karen, Dekker Evelien, Klausch Thomas, Lansdorp-Vogelaar Iris, van Leerdam Monique E, Hoogerbrugge Nicoline, Coupé Veerle M H

Abstract excerpt

To optimize surveillance in individuals with a family history (FH) of colorectal cancer (CRC), knowledge on the incidence rate of non-advanced adenomas (nAAs) and their progression rate to advanced neoplasia (AN) is crucial. We jointly estimated personalized adenoma incidence and progression rates using a novel statistical approach. We used data of individuals with ≥ 1 first-degree relative with CRC who underwent...

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Identifiers

PMID: 42133209
DOI: 10.1007/s10689-026-00565-0
PMCID: PMC13175997

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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