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Article

Limited use of interleukin 28B in the setting of response-guided treatment with detailed on-treatment virological monitoring.

Hepatology (Baltimore, Md.) - 2 Sept 2011

Mangia Alessandra, Thompson Alexander J, Santoro Rosanna, Piazzolla Valeria, Copetti Massimiliano, Minerva Nicola, Petruzzellis Daniela, Mottola Leonardo, Bacca Donato, McHutchison John G

Abstract excerpt

UNLABELLED: A single-nucleotide polymorphism upstream of the interleukin-28B (IL28B) gene is associated with pegylated interferon-alfa-induced viral clearance in hepatitis C virus (HCV) genotype 1 patients. Using a well-characterized cohort of patients randomized to standard versus response-guided therapy, we studied whether the favorable CC type allows shortening of treatment duration. Association with viral...

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PMID: 21626525
DOI: 10.1002/hep.24458

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