Article
Absence of mutation at the 5'-upstream promoter region of the TPM4 gene from cardiac mutant axolotl (Ambystoma mexicanum).
Cardiovascular toxicology - 1 Sept 2011
Denz Christopher R, Zhang Chi, Jia Pingping, Du Jianfeng, Huang Xupei, Dube Syamalima, Thomas Anish, Poiesz Bernard J, Dube Dipak K
Abstract excerpt
Tropomyosins are a family of actin-binding proteins that show cell-specific diversity by a combination of multiple genes and alternative RNA splicing. Of the 4 different tropomyosin genes, TPM4 plays a pivotal role in myofibrillogenesis as well as cardiac contractility in amphibians. In this study, we amplified and sequenced the upstream regulatory region of the TPM4 gene from both normal and mutant axolotl...
Topics
- Ambystoma mexicanum
- Animals
- Base Sequence
- CHO Cells
- Cricetinae
- Cricetulus
- Gene Expression Regulation
- Genes, Reporter
- Genotype
- Mice
- Molecular Sequence Data
- Mutation
- Myocardium
- Phenotype