Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Loss of p19Arf in a Rag1(-/-) B-cell precursor population initiates acute B-lymphoblastic leukemia.

Blood - 21 Jul 2011

Hauer Julia, Mullighan Charles, Morillon Estelle, Wang Gary, Bruneau Julie, Brousse Nicole, Lelorc'h Marc, Romana Serge, Boudil Amine, Tiedau Daniela, Kracker Sven, Bushmann Frederic D, Borkhardt Arndt, Fischer Alain, Hacein-Bey-Abina Salima, Cavazzana-Calvo Marina

Abstract excerpt

In human B-acute lymphoblastic leukemia (B-ALL), RAG1-induced genomic alterations are important for disease progression. However, given that biallelic loss of the RAG1 locus is observed in a subset of cases, RAG1's role in the development of B-ALL remains unclear. We chose a p19Arf(-/-)Rag1(-/-) mouse model to confirm the previously published results concerning the contribution of CDKN2A (p19ARF /INK4a) and RAG1...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigens, CD19
Share to Antigens, CD34

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Antigens, Ly

Share to Gene Expression Regulation, Leukemic

Share to Neoplasm Transplantation

Share to Precursor B-Cell Lymphoblastic Leukemia-Lymphoma

Share to Receptor, Notch1

Share to Stromal Cells

Source

Open in PubMed Open full text

Identifiers

PMID: 21622646
DOI: 10.1182/blood-2010-09-305383
PMCID: PMC3142899

Genes

RAG1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Loss of p19Arf in a Rag1(-/-) B-cell precursor population initiates acute B-lymphoblastic leukemia.PMID 21622646Read ↗

B-lineage transcription factors and cooperating gene lesions required for leukemia development.Semantic proximity Read ↗

Progenitor B-1 B-cell acute lymphoblastic leukemia is associated with collaborative mutations in 3 critical pathwaysSemantic proximity Read ↗

ADAR1 is vital for B cell lineage development in the mouse bone marrowSemantic proximity Read ↗

The INK4-ARF (CDKN2A/B) locus in hematopoiesis and BCR-ABL-induced leukemias.Semantic proximity Read ↗

Transcription from the RAG1 locus marks the earliest lymphocyte progenitors in bone marrow.Semantic proximity Read ↗

Signals from the bone marrow B cell niches shape pre-leukemic fate in a murine model of B cell acute lymphoblastic leukemia.Semantic proximity Read ↗

B-cell acute lymphoblastic leukaemia: towards understanding its cellular origin.Semantic proximity Read ↗

Dysregulation of PAX5 causes uncommitted B cell development and tumorigenesis in miceSemantic proximity Read ↗

Notch1 gene mutations target KRAS G12D-expressing CD8+ cells and contribute to their leukemogenic transformation.Semantic proximity Read ↗

Epigenetic regulation of the Ink4a-Arf (Cdkn2a) tumor suppressor locus in the initiation and progression of Notch1-driven T cell acute lymphoblastic leukemia.Semantic proximity Read ↗

An instructive role for IL7RA in the development of human B-cell precursor leukemiaSemantic proximity Read ↗

Deletion-based mechanisms of Notch1 activation in T-ALL: key roles for RAG recombinase and a conserved internal translational start site in Notch1.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.