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Article

Let‐7 modulates acquired resistance of ovarian cancer to Taxanes <i>via</i> IMP‐1‐mediated stabilization of multidrug resistance 1

26 May 2011

Abstract excerpt

Ovarian cancer patients frequently develop resistance to chemotherapy regiments using Taxol and carboplatin. One of the resistance factors that protects cancer cells from Taxol-based therapy is multidrug resistance 1 (MDR1). micro(mi)RNAs are small noncoding RNAs that negatively regulate protein expression. Members of the let-7 family of miRNAs are downregulated in many human cancers, and low let-7 expression has...

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PMID: 21618519
DOI: 10.1002/ijc.26190

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